Feature Subspace Based Ensemble Classifier
Sigma promoter sequences in bacterial genomes are important due to their role in transcription initiation. Sigma 70 is one of the most important and crucial sigma
factors. In this paper, we address the problem of identification of σ70 promoter sequences in bacterial genome. We propose iPromoter-FSEn, a novel predictor for
identification of σ70 promoter sequences. Our proposed method is based on a feature subspace based ensemble classifier. A large set of of features extracted from the
sequence of nucleotides are divided into subsets and each subset is given to individual single classifiers to learn. Based on the decisions of the ensemble an aggregate
decision is made by the ensemble voting classifier. We tested our method on a standard benchmark dataset extracted from experimentally validated results.
Experimental results shows that iPromoter-FSEn significantly improves over the state-of-the art σ70 promoter sequence predictors. The accuracy and area under
receiver operating characteristic curve of iPromoter-FSEn are 86.32% and 0.9319 respectively. We have also made our method readily available for use as a web application.